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A potential option for the next step of your treatment journey with multiple sclerosis (MS) flares

Cortrophin Gel is a prescription medicine that is injected under the skin or into the muscle. It is used for treatment for acute attacks or flares of multiple sclerosis.

Learn about MS flares and Cortrophin Gel.

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Meet

  • 52 years old, tour guide  
  • Diagnosed with MS 6 years ago 
  • She was on treatment to help stabilize her condition and then experienced a flare 
  • She was prescribed a high dose of steroids 
  • Cathy called into the office reporting that her flare continues and she's looking to see if there's anything else that may help
“
I’m worried about this disease and want to know about all of my options.”

About MS flares

“Flares” are when symptoms suddenly become worse. If your MS symptoms keep coming back, even after or on treatment, you’re not alone. 

Nearly 3 in 4 patients with MS experience occasional flare-ups of symptoms, including fatigue, numbness or tingling, and walking or balance issues.

MS flares are characterized by the occurrence of new symptoms, or the worsening of old symptoms

A flare is defined as at least 24 hours of symptom presence, with at least 30 days of separation since your previous flare

Both unresolved flares and the frequency of flares in the first 1-2 years of the disease can impact progression of disability

See where Cortrophin Gel may fit into your treatment plan

Cortrophin Gel is an FDA-approved therapy available only by prescription as an additional treatment option for appropriate patients.

Your healthcare provider may have prescribed Cortrophin Gel for acute attacks or flares of multiple sclerosis because you are on other medicines and are in need of an additional therapy option.

You’ll get specific instructions from your healthcare provider on how to use Cortrophin Gel based on your specific condition and therapy needs.

If you’re ready to take the next step in your treatment journey, talk with your healthcare provider to understand if Cortrophin Gel is an appropriate option.

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Learn about multiple sclerosis flares and Cortrophin Gel

Download
Patient Brochure
Understanding the
Role of ACTH

See how adrenocorticotropic hormone (ACTH) may work.

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Learn more about
injecting Cortrophin Gel

Explore resources to help you learn how to inject Cortrophin Gel, including a video, step-by-step instructions, and other helpful tools.

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What is Purified Cortrophin Gel?
Important Safety Information
Expand ISI
What is Purified Cortrophin
Gel?Expand ISI

Purified Cortrophin Gel is used for:

  • Acute attacks or flares of multiple sclerosis.
  • Short-term add-on therapy to help manage acute episodes or flares in rheumatoid arthritis, including juvenile rheumatoid arthritis; psoriatic arthritis; ankylosing spondylitis; and acute gouty arthritis.
  • Treatment for flares or as maintenance therapy in select cases of systemic lupus erythematosus and systemic dermatomyositis (polymyositis).
  • Treatment for severe skin reactions (Stevens-Johnson syndrome) and severe psoriasis.
  • Treatment for atopic dermatitis (eczema) and serum sickness.
  • Treatment for severe acute and chronic allergic and inflammatory conditions affecting different parts of the eye. This can include the front part of the eye such as the cornea and iris, or the back part of the eye such as the optic nerve and retina.
  • Treatment for people with symptoms of sarcoidosis.
  • Reduction of protein in the urine of people with nephrotic syndrome of the idiopathic type (unknown origin) without uremia (accumulation of urea in the blood due to malfunctioning kidneys) or due to lupus.

Purified Cortrophin Gel is a prescription medicine that is injected under the skin or into the muscle. It is used for:

  • Short-term add-on therapy to help manage acute episodes or flares in rheumatoid arthritis, including juvenile rheumatoid arthritis; psoriatic arthritis; ankylosing spondylitis; and acute gouty arthritis.
  • Treatment for flares or as maintenance therapy in select cases of systemic lupus erythematosus and systemic dermatomyositis (polymyositis).
  • Treatment for severe skin reactions (Stevens-Johnson syndrome) and severe psoriasis.
  • Treatment for atopic dermatitis (eczema) and serum sickness.
  • Treatment for severe acute and chronic allergic and inflammatory conditions affecting different parts of the eye. This can include the front part of the eye such as the cornea and iris, or the back part of the eye such as the optic nerve and retina.
  • Treatment for people with symptoms of sarcoidosis.
  • Reduction of protein in the urine of people with nephrotic syndrome of the idiopathic type (unknown origin) without uremia (accumulation of urea in the blood due to malfunctioning kidneys) or due to lupus.
  • Acute attacks or flares of multiple sclerosis.
Important Safety InformationExpand ISI

DO NOT use Cortrophin Gel if you have any of the following conditions:

  • A skin condition called scleroderma
  • Bone density loss or osteoporosis
  • Fungal infections
  • Ocular herpes simplex (an eye infection)
  • A recent surgery
  • Stomach ulcers or a history of stomach ulcers
  • Heart failure
  • High blood pressure
  • Allergies to pig-derived proteins
  • Adrenal glands that do not make enough of the hormone cortisol (primary adrenocortical insufficiency) or
  • An adrenal cortex that makes too much of the hormones cortisol and aldosterone (adrenocortical hyperfunction)

Tell your doctor if you:

  • Have or have had any other health problems
  • Are taking any prescription or over-the-counter medicines, including aspirin, vitamins, and herbal or dietary supplements
  • Have any allergies
  • Are about to receive any vaccine
  • Are pregnant or plan to become pregnant. Cortrophin Gel may harm your unborn baby.
  • Are breastfeeding or plan to breastfeed. It is not known if Cortrophin Gel passes into your breast milk and if it can harm your baby.
What important information do I need to know about Cortrophin Gel?

Be sure to take Cortrophin Gel exactly as your doctor has directed. Always inject Cortrophin Gel under the skin or into the muscle. Do not inject Cortrophin Gel directly into the vein.

  • You may be more likely to get infections. Contact your doctor at the first sign of an infection or fever.
  • Your body may not produce enough natural cortisol after you stop taking Cortrophin Gel long term. This is called adrenal insufficiency. Your doctor may try to reduce your dosage gradually or prescribe a steroid medicine to protect you until the adrenal gland recovers.
  • You might develop high blood pressure, retain too much salt and water, or have low blood potassium levels. As a result of this, your doctor may recommend some changes to your diet, such as eating less salt or taking certain supplements.
  • Corticotropin therapy may hide symptoms of other diseases. This can make it more difficult for your doctor to make a diagnosis if something else is going on.
  • Taking Cortrophin Gel can make you feel irritable or depressed. You may also have mood swings or trouble sleeping.
  • You might develop certain eye conditions, such as cataracts, glaucoma, or optic nerve damage.
  • You may develop allergies to Cortrophin Gel. Signs of an allergic reaction include dizziness, nausea and vomiting, shock, and skin reactions.
  • The effects of Cortrophin Gel may be intensified if you have an underactive thyroid or cirrhosis of the liver.

Side effects of Cortrophin Gel include fluid or salt retention; weight gain; muscle weakness; osteoporosis, stomach ulcers with possible bleeding; injection site reactions; impaired wound healing; high blood pressure; convulsions; headache; development of Cushingoid state (a hormonal condition often characterized by facial puffiness and weight gain); and suppression of growth in children.

These are not all of the possible side effects of Cortrophin Gel. Call your doctor or pharmacist for medical advice about side effects. You may report side effects to ANI Pharmaceuticals, Inc. at 1-800-308-6755 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full Prescribing Information.


What is Purified Cortrophin Gel?

Purified Cortrophin Gel is a prescription medicine that is injected under the skin or into the muscle. It is used for:

  • Short-term add-on therapy to help manage acute episodes or flares in rheumatoid arthritis, including juvenile rheumatoid arthritis; psoriatic arthritis; ankylosing spondylitis; and acute gouty arthritis.
  • Treatment for flares or as maintenance therapy in select cases of systemic lupus erythematosus and systemic dermatomyositis (polymyositis).
  • Treatment for severe skin reactions (Stevens-Johnson syndrome) and severe psoriasis.
  • Treatment for atopic dermatitis (eczema) and serum sickness.
  • Treatment for severe acute and chronic allergic and inflammatory conditions affecting different parts of the eye. This can include the front part of the eye such as the cornea and iris, or the back part of the eye such as the optic nerve and retina.
  • Treatment for people with symptoms of sarcoidosis.
  • Reduction of protein in the urine of people with nephrotic syndrome of the idiopathic type (unknown origin) without uremia (accumulation of urea in the blood due to malfunctioning kidneys) or due to lupus.
  • Acute attacks or flares of multiple sclerosis.

Purified Cortrophin Gel is used for:

  • Acute attacks or flares of multiple sclerosis.
  • Short-term add-on therapy to help manage acute episodes or flares in rheumatoid arthritis, including juvenile rheumatoid arthritis; psoriatic arthritis; ankylosing spondylitis; and acute gouty arthritis.
  • Treatment for flares or as maintenance therapy in select cases of systemic lupus erythematosus and systemic dermatomyositis (polymyositis).
  • Treatment for severe skin reactions (Stevens-Johnson syndrome) and severe psoriasis.
  • Treatment for atopic dermatitis (eczema) and serum sickness.
  • Treatment for severe acute and chronic allergic and inflammatory conditions affecting different parts of the eye. This can include the front part of the eye such as the cornea and iris, or the back part of the eye such as the optic nerve and retina.
  • Treatment for people with symptoms of sarcoidosis.
  • Reduction of protein in the urine of people with nephrotic syndrome of the idiopathic type (unknown origin) without uremia (accumulation of urea in the blood due to malfunctioning kidneys) or due to lupus.
Important Safety Information

DO NOT use Cortrophin Gel if you have any of the following conditions:

  • A skin condition called scleroderma
  • Bone density loss or osteoporosis
  • Fungal infections
  • Ocular herpes simplex (an eye infection)
  • A recent surgery
  • Stomach ulcers or a history of stomach ulcers
  • Heart failure
  • High blood pressure
  • Allergies to pig-derived proteins
  • Adrenal glands that do not make enough of the hormone cortisol (primary adrenocortical insufficiency) or
  • An adrenal cortex that makes too much of the hormones cortisol and aldosterone (adrenocortical hyperfunction)

Tell your doctor if you:

  • Have or have had any other health problems
  • Are taking any prescription or over-the-counter medicines, including aspirin, vitamins, and herbal or dietary supplements
  • Have any allergies
  • Are about to receive any vaccine
  • Are pregnant or plan to become pregnant. Cortrophin Gel may harm your unborn baby.
  • Are breastfeeding or plan to breastfeed. It is not known if Cortrophin Gel passes into your breast milk and if it can harm your baby.
What important information do I need to know about Cortrophin Gel?

Be sure to take Cortrophin Gel exactly as your doctor has directed. Always inject Cortrophin Gel under the skin or into the muscle. Do not inject Cortrophin Gel directly into the vein.

  • You may be more likely to get infections. Contact your doctor at the first sign of an infection or fever.
  • Your body may not produce enough natural cortisol after you stop taking Cortrophin Gel long term. This is called adrenal insufficiency. Your doctor may try to reduce your dosage gradually or prescribe a steroid medicine to protect you until the adrenal gland recovers.
  • You might develop high blood pressure, retain too much salt and water, or have low blood potassium levels. As a result of this, your doctor may recommend some changes to your diet, such as eating less salt or taking certain supplements.
  • Corticotropin therapy may hide symptoms of other diseases. This can make it more difficult for your doctor to make a diagnosis if something else is going on.
  • Taking Cortrophin Gel can make you feel irritable or depressed. You may also have mood swings or trouble sleeping.
  • You might develop certain eye conditions, such as cataracts, glaucoma, or optic nerve damage.
  • You may develop allergies to Cortrophin Gel. Signs of an allergic reaction include dizziness, nausea and vomiting, shock, and skin reactions.
  • The effects of Cortrophin Gel may be intensified if you have an underactive thyroid or cirrhosis of the liver.

Side effects of Cortrophin Gel include fluid or salt retention; weight gain; muscle weakness; osteoporosis, stomach ulcers with possible bleeding; injection site reactions; impaired wound healing; high blood pressure; convulsions; headache; development of Cushingoid state (a hormonal condition often characterized by facial puffiness and weight gain); and suppression of growth in children.

These are not all of the possible side effects of Cortrophin Gel. Call your doctor or pharmacist for medical advice about side effects. You may report side effects to ANI Pharmaceuticals, Inc. at 1-800-308-6755 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full Prescribing Information.